Aging and microenvironment remodeling
We investigate age-associated rewiring of fibroblast and immune signaling to uncover mechanisms that can be therapeutically targeted.
Johns Hopkins · Oncology
Studying the tumor microenvironment in GI cancers
Research Focus
Tumor microenvironment biology across GI cancers
IDH1-mutant cholangiocarcinoma biology
We develop mechanistic and translational models to define immune microenvironment vulnerabilities in this distinct GI cancer subtype.
Lab Strategy
Working to improve our understanding of GI cancers
Mechanism Discovery
Dissect stromal, immune, and microenvironmental pathways that drive GI cancers.
Model Innovation
Create clinically relevant models spanning pancreatic and biliary malignancies.
Translational Testing
Evaluate tractable targets to inform therapeutic development and patient benefit.
Publications
Recent publication highlights
Recent Highlight
Age-related divergence of circulating immune responses in patients with solid tumors treated with immune checkpoint inhibitors
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Tumor-derived CCL2 drives tumor growth and immunosuppression in IDH1-mutant cholangiocarcinoma
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